Capsular polysaccharide adhesin antigen, preparation, purification and use

Abstract From the Canadian patent

A substantially pure capsular exopolysaccharide adhesin of coagulase-negative staphylococcal strains and a general, method to prepare such adhesins are described. Vaccines, composed of such adhesins and uses of such adhesins to, produce polyclonal and monoclonal antibodies against such adhesins, are also disclosed. The adhesins are useful in coating polymeric medical materials to prevent colonization by coagulase-negative staphylococcal strains and as a probe in, selecting desirable polymeric medical materials. Such adhesin antibodies are useful in vivo to prevent infection by nosocomial coagulase-negative staphylococcal strains in assays, for the dection of such bacteria in assays for the …