Oral sustained release acetaminophen formulation and process

Abstract From the Canadian patent

An acetaminophen-sustained release tablet or tablet layer is formed by making a wet granulation using, Povidone (PVP) in water or alcohol-water as the granulating fluid which is mixed with acetaminophen hydroxyethyl cellulose, a wicking agent e.g. microcrystalline cellulose then drying and milling the, granulation and blending with dry powdered erosion promoter, e.g. pregelatinized starch, wicking agent lubricant e.g. magnesium stearate and glidant e.g. silicon dioxide, and compressing the resultant granulation which, upon administration results in a slow release of the acetaminophen.