Poly-4-aminopyrrole-2-carboxamido derivatives and their use as site specific alkylating agents

Abstract From the Canadian patent

The invention relates to distamycin A analogs of the following formula, wherein n is 2, 3 or 4; A is an optionally substituted divalent radical chosen from , , , and -Het- wherein Het is a pentatomic or hexatomic heteromonocyclic ring, except pyrrole; and wherein either one of R1 and R2 is hydrogen and the other is an acylating moiety or R1 and R2 are both hydrogen or both alkyl groups optionally substituted, including the pharmaceutically acceptable salts of the said compounds. The compounds of the invention can be useful antitumor and antiviral agents.