Monoclonal antibodies to cyclosporins

Abstract From the Canadian patent

Novel monoclonal antibodies capable of distinguishing between cyclosporins, e.g. Cyclosporine, and metalbolites e.g. Cyclo-, sporins 17 and 18, are produced e.g. starting from novel, cyclosporins having an activated coupling group e.g. activated, carboxy group, e.g. (i) (0-succinimidooxysuccinyl)-Thr2- Cyclosporine and (ii) (N-.epsilon.-succinimidooxysuccinyl)-(D)Lys8- Cyclosporine. Cyclosporin starting materials required for the production of cyclosporins of type (ii) e.g. (D)Lys8-Cyclo-, sporine are also new and additionally have utility in the preparation of novel labelled cyclosporin derivatives as well as, antibodies and antisera generally. Also claimed are novel antigenic conjugates …