Method for synthesizing a peptide containing a non-peptide bond
CA 1307623 C · Owner: Coy, David H. · Inventors: Hocart, Simon J.; Coy, David H.
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
This invention features a method for the solid phase synthesis of non-peptide bonds (CH2-NH) in polypeptide chains. These polypeptides are synthesized by standard procedures and the non-peptide bond synthesized by reacting an amino aldehyde and an amino acid in the presence of NaCNBH3. This invention also features somatostatin analogs with non-peptide bonds. This invention further features a solid phase method of chemically modifying a peptide. The method involves synthesizing .alpha.-N-R and side group N-R analogs of peptides, where R is an alkyl or aryl group by, reacting a carbonyl- containing compound and an amino acid in the presence of NaCNBH3.
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Granted September 15, 1992. A Canadian patent filed before October 1, 1989 lasted 17 years from grant, so its term ended September 15, 2009.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
Timeline From CIPO dates
Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.