PROCESS FOR THE PRODUCTION OF 17.alpha.-ETHINYL-17.beta.-HYDROXY-18-METHYL-4,15-ESTRADIEN-3-ONE AND NEW INTERMEDIATE PRODUCTS FOR THIS PROCESS
CA 1306993 C · Owner: Bohlmann, Rolf · Inventors: Hofmeister, Helmut; Bohlmann, Rolf; Wiechert, Rudolf
Overview
Its claims, description and drawings are in the Canadian Patents Database.
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A process for the production of 17?-ethinyl-17?hydroxy-18-methyl-4,15-estradien-3-one is described comprising reacting a 17-enolester of formula II II. wherein, R1 represents an alkyl radical with 1-3 carbon atoms and R2 represents an acyl or a trialkylsilyl group with 1-10 carbon atoms, under palladium catalysis with compounds of formula III, III, wherein R1 represents an alkyl radical with 1-3 carbons atoms reducing the 17-keto group to the 17-hydroxy group in a manner known in the art, reducing the aromatic A-ring according to Birch, with liquid ammonia to 3-methoxy-, 2,5(10),15-estratrien-17.beta.;-ol reoxidizing the 17-hydroxy, group to the 17-keto group ethinylating the 17-keto, group …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Granted September 1, 1992. A Canadian patent filed before October 1, 1989 lasted 17 years from grant, so its term ended September 1, 2009.
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