Tylosin derivatives and processes for producing the same

Abstract From the Canadian patent

Tylosin derivatives represented by the following general formula (I):, (I), wherein R denotes a hydrogen atom acetyl, propionyl or a, radical of Si(R2)3 (in which R2 is a lower alkyl group); with the proviso that, when R1 is hydrogen R is not Si(R2)3, and R1 stands for a hydrogen atom or a radical of Si(R2)3 are novel compounds, which are useful as intermediates for the synthesis of 4"-acyl derivatives of tylosin because after introduction of any desired acyl group at the 4"hydroxyl group, the silyl protective group can be readily removed without liberation of said acyl group. This invention also provides processes for producing said tylosin derivatives. More specifically, it provides a …