Single-stage process for preparing mixed-substituted 1,2-diacyl-sn-glycero-3-phosphocholines

Abstract From the Canadian patent

Single-stage process for preparing mixed-substituted enantiomerically pure 1,2-diacyl-sn-glycero-3phosphocholines of the general formula I (I), in which R1 and R2 are different and independently of each other denote a substituted or unsubstituted C1 to C24-alkyl or C3 to C24-alkenyl radical, by reacting 1-0-triphenylmethyl-2-acyl-sn-glycero-3-phosphocholine of the general formula II of the sheet of formulae, in which T denotes a substituted or unsubstituted triphenylmethyl group and R2 is as defined above, with a reactive carboxylic acid derivative of the general formula III of the sheet of formulae in which R1 is as defined above and X denotes a carboxylic acid radical, a carbonic acid …