N-alkenyl-3-hydroxybenzo¬b thiophene-2- carboxamide derivatives as dualcyclooxygenase and lipoxygenase inhibitors

Abstract From the Canadian patent

1737M/0677A, 17023IA, TITLE OF THE INVENTION N-ALKENYL-3-HYDROXYBENZObTHIOPHENE-, 2-CARBOXAMIDE DERIVATIVES AS DUAL CYCLOOXYGENASE AND LIPOXYGENASE INHIBITORS, ABSTRACT OF THE DISCLOSURE N-Alkenyl-3-hydroxybenzobthiophene-2-, carboxamide derivatives have been prepared by: 1) treating a substituted 2-halobenzoate with thioacetamide followed by N-alkenylation with appropriate agents, such as aldehydes ketones, enol ethers, epoxides, acetals or ketals;, 2) treating a substituted thiosalicylate with an appropriately substituted haloacetamide followed by dehydration; and, 3) further synthetic modification of compounds prepared above. 1737M/0677A - 2 - 17023IA These compounds have been found to …