Messenger rna stabilization in animal cells
CA 1297435 C · Owner: Damon Biotech, Inc. · Inventors: Gillies, Stephen D.
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
of the Invention, Disclosed is a method of increasing production of proteins, e.g. human tPA in mammalian, cells which normally secrete immunoglobulins. Degradation of mRNA transcribed from recombinant DNA is decreased by decreasing the length of the untranslated region of the mRNA. The untranslated region of DNA encoding a protein of interest is altered to produce a shorter recombinant DNA having an untranslated region comprising a poly A addition signal (AATAAA) and less than about 300 nucleotide bases interposed between said poly A signal and the stop codon 3' of the coding region of the gene of interest. The mammalian cell line is transfected and cultured to produce greater amounts of …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Granted March 17, 1992. A Canadian patent filed before October 1, 1989 lasted 17 years from grant, so its term ended March 17, 2009.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
Timeline From CIPO dates
Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.