Process for producing chiral glycine derivatives

Abstract From the Canadian patent

By a simple enantiomer separation of 1,3-imidazolin- 4-ones produced from glycine esters, primary alkyl amines and pivaldehyde and having the general formula (II), wherein R represents a straight-chain or branched C1 to C4 alkyl group with a chiral acid, chiral glycine derivatives having the general formula, (I), wherein R is as above * represents an asymmetry centre and R1 represents a phenyl or benzyl group, a phenoyl-oxy or benzyloxy group, preferably the phenyl group or a phenyl group monoor tri-substituted in any ring portion by a C1 to C4-alkyl or alkoxy group are readily accessible. On diastereo-selective .alpha.-alkylation they result in branched and non-branched proteinogenic or …