Purification of synthetic oligomers

Abstract From the Canadian patent

Oligomers and polymers are prepared substantially free of error sequences by sequentially adding monomers, which are terminally blocked and have active functionalities protected, to a growing chain bound to a support through a selectively cleavable linkage. After each addition unblocked terminal groups are, capped. At the completion of monomer addition enzyma-, tic hydrolysis interfering protecting groups axe removed along with the capping group and failure sequences enzymatically degraded. The terminal blocking group may then be removed. The completed oligomer or polymer may be cleaved from the support prior or subsequent to enzymatic degradation but after completion of the sequent