N-6 substituted adenosine derivatives as cardiac vasodilators

Abstract From the Canadian patent

New, N-6 monosubstituted adenosine derivatives are disclosed which have significant cardiac vasodilatory effect. The compounds of the invention include 6-(cyclo-butyl amino) - 9 - (?-D-ribofuranosyl) - 9H - purine 6 - (2 - methyl - 2 -, phenyl hydrazino) - 9 - (?-D-ribofuranosyl) - 9H - purine and, compounds of the general formula: wherein R1 is H, lower alkyl, lower alkoxy alkylamino, or, arylamino, R2 is H, lower alkyl hydroxymethyl, phenyl or, substituted phenyl R3 is H, lower alkyl, phenyl, substituted phenyl, R3 is H, lower alkyl, phenyl, substituted phenyl 2-, or 3-thienyl, or 2- or 3-pyridyl, R4 is H or lower alkyl and, R5 is H or lower acyl. Particularly active as a cardiac …