Compositions comprising 1-substituted azacycloalkanes

Abstract From the Canadian patent

This invention provides compositions comprising a physiologically-active agent and a compound having the structural formula, wherein each X, Y and Z may represent oxygen sulfur or, two hydrogen atoms, provided however that when Z, represents two hydrogen atoms, both X and Y represent oxygen or sulfur and when Z represents oxygen or sulfur at least one of X and Y must represent oxygen or sulfur; m is 2-6; R' is H or a lower alkyl group having 1-4 carbon atoms; n is 0-17 and R is -CH3, or , wherein R'' is H or halogen in an amount effective to enhance the penetration of the physiologically-active agent through the skin or other membrane of the body of an animal.