Derivatives of 5-pentylamino-5-oxopentanoic and 4- pentylamino-4-oxobutanoic acids with antagonistic activity towards cholecystokinin and a method for their preparation

Abstract From the Canadian patent

New original derivatives are described of 5-pentylamino -5-oxopentanoic and 4-pentylamino-4-oxobutanoic acids having the formula:, in which n is 1 or 2 R1 is selected from the groups, 2 naphthyl 2 (or 3)-quinolinyl, 2 (or 3)-indolyl, 2 (or 3)-benzofuranyl, 2 (or 3)-benzothiophenyl and R2, is a pentyl group or an alkoxyalkyl group with 4 or 5 carbon atoms, preferably pentyl, 2-ethoxyethyl 3-methoxypropyl or 3 ethoxypropyl. The compounds have a powerful antagonistic activity towards cholecystokinin and are particularly useful in the treatment of illnesses of the digestive system such as colitis, biliary diskinesia, pancreatitis or in the treatment of disorders of the central nervous system …