Anti-atherosclerotic trisubstituted ureas and thioureas

Abstract From the Canadian patent

Trisubstituted ureas and thioureas useful as antiatherosclerotic agents, compositions thereof and processes for their preparation are disclosed. These compounds are of the general formula:, wherein X is a substituent selected for example, from alkyl, alkenyl, alkinyl alkoxy, alkylthio and alkanoyl each with 1 to 4 carbon atoms or from such groups as nitro cyano, phenyl and, tolyl, Y is oxygen or sulfur and R1 and R2 are such groups as C5-C12 alkyl or alkenyl, alkinyl, cycloalkyl each wlth 4 to 12 carbon atoms or C7-C14 aralkyl.