1- or 3-monosubstituted 2-oxindole compound intermediates useful for the production of analgesic and anti-inflammatory agents

Abstract From the Canadian patent

Disclosed are novel 1- or 3-monosubstituted 2-oxindole compounds useful as intermediates for the preparation of analgesic and anti-inflammatory 1,3-disubstituted 2-oxindole compounds. The intermediates have the formulae: and , The 1,3-disubstituted 2-oxindole compounds have the formula: X is H, halo, alkyl, alkoxy, alkylthio CF3, alkylsulfinyl, alkylsulfonyl, nitro phenyl, alkanoyl, benzoyl, thenoyl, alkanamido, benzamido or N,N-dialkylsulfamoyl; Y is H halo, alkyl, alkoxy, cycloalkyl, alkylthio or CF3; or X and Y together form methylenedioxy, ethylenedioxy or with the carbon atoms to which they are attached, a cycloalkane or aromatic ring; R1 is alkyl cycloalkyl, phenyl, phenylalkyl, …