Dihydrobenzo¬b thiophenes and pharmaceutical compositions thereof useful as antifungals

Abstract From the Canadian patent

2-Alkyl-, 2-alkenyl- and 2-alkynyl-2,3-dihydro-2- (1H-azolyl(C1-C2)alkyl)benzobthiophenes especially 2-alkyl- 2-alkenyl- and 2-alkynyl-2,3-dihydro-3-hydroxy-2-(1H-1imidazolylmethyl)-4-, 5-, 6- and 7-halobenzo-bthiophenes and related derivatives having antifungal activity are disclosed. Pharmaceutical compositions comprising compounds of the invention and their use in treating fungal infections in susceptible hosts such as humans are also disclosed. These compounds have the following formula, wherein X is halogen or an organic radical such as (lower)alkyl Y is substituted or unsubstituted imidazolyl or 1,2,4-triazolyl or phenyl(lower)alkyl, R, and R2 are hydrogen or an organic radical such …