Bisphosphonic acid derivatives, their production and use

Abstract From the Canadian patent

Novel compounds of Formula I (I), or pharmaceutically-acceptable salts thereof or pharma-, ceutically-acceptable in vivo hydrolyzable esters thereof are provided herein. In such Formula, R1-R11 can be the same or different and stand for hydrogen, a straight branched or cyclic, C1-C10 hydrocarbon radical phenyl or a phenyl-C1-C4-alkyl, radical; n is zero or one and m is zero, one or two; or R2 and, R4 when taken together form an unsubstituted saturated aliphatic 5-, 6- or 7- membered ring or a saturated aliphatic 5- 6- or 7-, membered ring which is substituted with one or more C1-C4-alkyl radicals. Such compounds are valuable in human and veterinary practice by reducing bone resorption and …