Cell line producing aids viral antigens without producing infectious virus particles
CA 1286619 C · Owner: The United States Of America, Represented By The Secretary, U.S. Departm Ent Of Commerce · Inventors: Martin, Malcolm A.; Folks, Thomas M.; Powell, Douglas M.
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
Leu-3- cells surviving infection with the AIDS retrovirus can be induced with IUdR to express infectious virus. A cellular clone (8E5), isolated by limiting dilution of a mass culture of survivor cells was found, to contain a single, integrated defective provirus that, was constitutively expressed. Although IUdR treatment of 8E5 cells failed to induce infectious virus cocultiva-, tion with Leu-3+ cells generated the characteristic syncytia associated with acute AIDS retrovirus infection. The single integrated copy of proviral DNA directs the synthesis of all major viral structural proteins except p64 and p34 as monitored by immunoblotting. Diagnostic reagents and kits in accordance with the …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Granted July 23, 1991. A Canadian patent filed before October 1, 1989 lasted 17 years from grant, so its term ended July 23, 2008.
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Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.