Process for the preparation of compounds containing carboxamide groups,in particular of peptides

Abstract From the Canadian patent

The invention relates to a process for the preparation of compounds containing carboxamide groups in, particular peptides, by reaction of compounds which contain a carboxyl group, in the presence of dialkylphosphinic anhydrides, with compounds which contain a free amino group, which comprises maintaining the hydrogen ion concentration of the reaction mixture within a defined range during the reaction by metering in a base and after, the reaction is complete, eliminating where appropriate, radicals introduced to protect other functional groups.