Naphthalene anti-psoriatic agents

Abstract From the Canadian patent

Psoriasis in mammals is relieved by topically administering naphthalenes of the formula: (I), wherein:, R1 and R2 are lower alkoxy or lower alkylthio; R3 is hydrogen, lower alkyl, lower alkoxy optionally substituted phenyl, optionally substituted phenyl lower alkyl, optionally substituted phenyl lower alkoxy, amino, lower alkylamino, lower dialkylamino halo, cyano, or S(O)nR wherein R is lower alkyl; optionally substituted phenyl; optionally substituted phenyl lower alkyl; or optionally substituted heterocyclic aryl of three to nine ring atoms containing one or two heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur, and the pharmaceutically acceptable acid …