Anti-viral and immunostimulatory polynucleotide duplex and use thereof
CA 1285481 C · Owner: University Of Maryland · Inventors: Ts'O, Paul O.P.; Aurelian, Laure
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
A drug has been provided which is a mismatched analog of rIn.rCn,rIn.r(C12,U)n. It retains the ability to induce interferon but does not evidence cellular toxicity. In vitro the drug treatment of HSV-2 infected human fibroblasts 0.25-2.5 mg/ml; 24 hrs. pre- to 1 hr. post infection (p.i.) results in 80% reduction in virus titers. In vivo antiviral activity was evaluated in a guinea pig model of recurrent HSV-2 infection. Guinea pigs were inoculated with HSV-2 (5x105 PFU in the footpad) and treated with 4 (2 day intervals) intraperitoneal injections of the rIn.r(C12,U)n (5 µg/g weight) or placebo (saline) beginning at 0- 24 hrs. p.i. They were followed for: (i) development and severity …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Granted July 2, 1991. A Canadian patent filed before October 1, 1989 lasted 17 years from grant, so its term ended July 2, 2008.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
Timeline From CIPO dates
Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.