Methods for purification of single-chain and double- chain tissue plasminogen activator
CA 1284961 C · Owner: Suzuki, Katsuyuki · Inventors: Ohoka, Masaharu; Morii, Noriko; Mori, Kunizo
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
A mixture containing a single-chain tissue plasminogen activator (tPA) and/or double-chain tPA is brought into close contact with a column carrying an immobilized Erythrina trypsin inhibitor as an affinity agent. Adsorbed proteins are eluted with eluents having different pHs with or without arginine or benzamidine so, that single-chain tPA is obtained in the eluent with a pH at least 4.5 and double-chain tPA is obtained in the eluent with a pH lower than 4.5.
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Granted June 18, 1991. A Canadian patent filed before October 1, 1989 lasted 17 years from grant, so its term ended June 18, 2008.
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Timeline
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Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.