¬4.2.0 bicyclooctane derivatives with valuable therapeutic properties

Abstract From the Canadian patent

Compounds useful in treating cardiovascular disorders such as thrombosis, hypertension and, atherosclerosis are compounds depicted in formulas (1) (2), and (3):, , (1) (2) (3), wherein: n is 2 or 3;, R1 is CH20H, CHO, CO2R or CO2H; R2 is hydrogen or methyl; and, R3 is linear or branched alkyl having 5-10 carbon atoms, optionally substituted with lower alkyl lower, alkoxy, trifluoromethyl, or halogen in which, a is 0, 1 or 2;, b is 3-7;, m is 0,1 or 2; and R is , wherein X is, -?-CH3, -NH?CH3, -?-C6H5 -NH?-C6H5, or, -NH?N(R4)2;, in which each R4 is independently hydrogen or lower alkyl having 1-6 carbon atoms and the pharmaceutically acceptable, non-toxic salts and esters thereof.