Isoindolin-1-one derivative and anti-arrhythmic agent

Abstract From the Canadian patent

Isoindolin-1-one compounds represented by the following formula (I);, (I), {wherein n represents an integer of 1 to 6; m represents 0 or 1; R1, R2 and R3 are each independently hydrogen or lower alkyl, and when m is 1, R1 and one of R2 and R3 may form a five-membered or six-membered ring over N atom; X represents hydrogen or hydroxy; Ar represents naphthyl pyridyl or, substituted phenyl represented by the formula (II); Ar and X may form a lactone ring;, (II), wherein Y represents carboxyl lower alkoxycarbonyl, carbamoyl, N,N-lower alkyl-substituted carbamoyl or amino represented by the formula (III):, (III) (wherein R6 and R7 are each independently hydrogen lower, alkyl or lower alkanoyl); …