3-amino-3,4,6-trideoxyglycals, processes for preparation thereof and anthracyclines obtained with the aid of these glycals

Abstract From the Canadian patent

Processes for preparing new 3-amino-3,4,6trideoxyglycals 14 and 15, and use of these new compounds for preparing anthracyclines are described. 14 15, The new glycals, of the general Formulae 14 and 15 are prepared by treating glycals of Formula 10 and 11, 11, with a mixture of sodium hydride and carbon disulfide and then with methyl iodide to obtain (S-methyl) dithiocarbonates of general Formula 12 and 13 12 13, the (S-methyl) dithiocarbonate groups of which are eliminated by reduction with tributyltin hydride in the presence of azobis (isobutyronitrile). The glycals of the Formulae 14 and 15 are used to prepare anthracyclines which can be used to prepare medicaments.