Derivatives of 4-phenyl-1,4-dihydropyridine-3, 5-dicarboxylic acid

Abstract From the Canadian patent

DERIVATIVES OF 4-PHENYL-1,4-DI-HYDROPYRIDINE-3 5-DICARBOXYLIC ACID, ABSTRACT OF THE DISCLOSURE Compounds are described of the formula (I), wherein, R1 and R4 independently represent a C1-4 alkyl group;, R2 and R3 independently represent a C1-6 straight or branched alkyl chain which may be interrupted by an oxygen atom;, R5 represents a straight or branched chain C1-13 alkyl group or a C5-8 cycloalkyl group which may be substituted by a C1-3 alkyl substitutent; The compounds represented by formula (I) reduce intracellular calcium ion concentration by limiting transmembranal calcium ion influx and thus may be useful for the treatment of cardiovascular disorders such as hypertension.