8-substituted nucleoside and purine derivatives, the process for the preparation thereof and the pharmaceutical compositions containing them

Abstract From the Canadian patent

New 8-substituted nucleoside and purine derivatives the process for the preparation, thereof and the pharmaceutical compositions containing them" ABSTRACT, New 8-substituted nucleoside and purine derivatives of the general formula: wherein R represents an amino group or an hydroxy group possibly in the corresponding keto tautomeric form, R1 is hydrogen or an amino group R2 is hydrogen or a .beta.-D-, ribofuranosyl radical wherein the primary hydroxy group and/or the two secondaryhydroxy groups may be derivatized R3 is an optionally substituted aryl or monocyclic heteroaryl radical and, X is -O- or -S-. The new compounds have antihyperlipaemic activity.