.alpha.-ALKYL POLYOLEFINIC CARBOXYLIC ACIDS AND DERIVATIVES THEREOF USEFUL IN THE TREATMENT OF PSORIASIS AND ALLERGIC RESPONSES

Abstract From the Canadian patent

Polyolefinic compounds represented by the general formula, in which R1 are each hydrogen or an alkyl group of from 1 to 5 carbon atoms; R2 is an alkyl group of from 1 to 5 carbon atoms; R3 is hydroxyl, alkoxy of from 1 to 5 carbon atoms NH2, NHR2 or NR2R2 and Z is cycloalkyl cycloalkenyl or, cycloalkdienyl group substituted with from 0 to 5 alkyl groups, a keto group or a hydroxyl group or a phenyl group substituted with from 0 to 4 hydroxy, alkoxy alkyl or, trifluoromethyl groups or halogen atoms or combinations thereof and the pharmaceutically acceptable salts thereof. The foregoing compounds have been found to be effective in the treatment of psoriasis inflammatory, conditions and …