Renin-inhibitory peptides and their use

Abstract From the Canadian patent

Compounds of formula, R1CO-NH-CH(R2)-CONH-CH(R3)-X wherein:, R1 represents alkyl having an .alpha.-amino or protected .alpha.-amino substituent and an aryl, heterocyclic or heterocyclic-dithio substituent;, R2 represents a variety of aliphatic and cycloaliphatic hydrocarbon groups, which may be substituted;, R3 represents isobutyl, sec-butyl benzyl or, (C3-C8 cycloalkyl)methyl; and X represents, a group of formula -CH(-A-R4)-Y (in which A represents a single bond or an alkylene group; R4 represents an optionally protected carboxy group, an optionally N-substituted carbamoyl group, an optionally N-substituted carbazoyl group or an acyl group; and Y represents a hydroxy group a, mercapto …