PROCESS FOR THE OPTICAL RESOLUTION OF RACEMIC MIXTURES OF .alpha.-NAPHTHYLPROPIONIC ACIDS

Abstract From the Canadian patent

A new process for the optical resolution of racemic mixtures of ?-naphthylpropionic acids of formula I, d,l, wherein R1 is (C1-6) alkyl and R2 represents hydrogen or a halogen atom. This process comprises reacting a racemic mixture of a compound of formula II, II, d,1 wherein R1 and R2 have the above seen meanings and R3 is a reactive group, with an optically active aminoacid of formula, III, d or l, wherein R4 represents a (C1-8) alkyl optionally sub-, stituted by a carboxy group phenyl, substituted phenyl, benzyl, substituted benzyl and m is an integer from 0 to 4, to give a pair of diastereoisomeric amides of formula IV, d,d + l,d or d,l + l,l, wherein R1 R2, R4 and m have the above seen …