Perhydrothiazepine derivatives, their preparation and their therapeutic use

Abstract From the Canadian patent

Compounds of formula (I): (I), (wherein: R1 represents an optionally substituted alkyl, cycloalkyl, aryl, partially hydrogenated aryl or heterocyclic group; R2, R3, R4 and R5 represent hydrogen or an optionally substituted alkyl cycloalkyl, aralkyl, aryl, heterocyclic or heterocyclic-alkyl group or any adjacent pair thereof form a cyclic structure at, least one not being hydrogen; A represents a bond or a, methylene, ethylene, oxymethyl or thiomethyl group; B represents an alkylene, alkylidene, cycloalkylene or cycloalkylidene group; and n is 0, 1 or 2) and salts and esters thereof are hypotensive agents.