Devices for the controlled release of active substances, as well as process for the preparation thereof

Abstract From the Canadian patent

The invention relates to a device for the controlled release of one or more active ingredients to a liquid particularly, a controlled release pharmaceutical tablet obtained by compressing a mixture of two granulates in a weight ratio of 30:70 to 70:30 said granulates having particle sizes of 0.4-2.0 mm. One of the granulates, the restraining phase granulate comprises one or more, active ingredients dispersed in a matrix of an insoluble substance and the other granulate, the housing phase granulate comprises a, soluble material and a penetration rate limiting material one, material optionally having both functions. In the compressed device, the granulates form two distinct phases each of …