Process for the optical resolution of racemic mixtures of o-naphthyl-propionic acids

Abstract From the Canadian patent

A new process for the optical resolution of racemic mixtures of ?-naphthyl-propinoic acids of formula I, where R1 is an alkyl group, straight or branched having, from 1 to 6 carbon atoms, and R2 represents a hydrogen or a halogen atom. This process comprises reacting a racemic mixture of a compound of formula II, I I d,l, wherein R1 and R2 have the above seen meanings and R3 is a reactive group, with an optica1ly active compound of formmula, R4-NH2 III, wherein R4 is the residue of a primary or secondary alcohol which, taken with the NH2 radical, forms an optically active .beta.-aminoalcohol, to give a pair of diastereoisomeric amides of formula, IV, d,d + l,d or d,l + l,l wherein R1, R2 …