Process for the preparation of thieno (2,3-d)- imidazole derivatives and pharmaceutically acceptable acid addition salts thereof

Abstract From the Canadian patent

Process for the preparation of novel derivatives of -thieno(2,3-d)imidazoles of the formula I, in which R1 denotes hydrogen, lower alkyl chlorine, bromine, acetyl, cyclopropylcarbonyl methoxycarbonyl or, ethoxycarbonyl, R2 denotes hydrogen or lower alkyl R3, r5 and R6 independently of one another denote hydrogen or lower alkyl, R4 denotes hydrogen or lower alkoxy and n denotes 0 or 1, and of pharmaceutically acceptable acid addition salts thereof, this process comprising reacting a compound of the formula, II, with a compound of the formula III, wherein X represents chlorine or bromine in the presence of, a strong base, and if appropriate partially oxidizing the - 2 -, compounds of formula …