Process for the in-situ preparation of liposomes and their use as a sustained-release aerosol delivery system

Abstract From the Canadian patent

A process for the preparation of liposomes which comprises spraying micro-fine droplets of a composition comprising substantially pure phospholipid in a volatile liquid carrier to impinge either upon or below an aqueous surface thereby forming liposomes at the said surface. The compositions may include drug molecules dissolved therein and upon formation of the liposomes drug molecules are entrapped. The entrapment of drug molecules in this manner provides a method of sustained release of drug molecules.