Heterocyclic-substituted quinolone inotropic agents

Abstract From the Canadian patent

9387-64, Abstract of the Disclosure, A quinolone inotropic agent of the formula:- --- (I), or a pharmaceutically acceptable salt thereof wherein "Het" is an optionally, substituted 5- or 6-membered monocyclic aromatic heterocyclic group attached by a carbon atom to the 5-, 6-, 7- or 8- position of said quinolone; R which is, attached to the 5-, 6-, 7- or 8- position is hydrogen, C1-C4 alkyl; C1-C4, alkoxy C1-C4 alkylthio, C1-C4 alkylsulphinyl, C1-C4 alkylsulphonyl halo, CF3, hydroxy, hydroxymethyl, or cyano; R1 is hydrogen cyano, (C1-C4 alkoxy)-, carbonyl, C1-C4 alkyl nitro, halo, -NR3R4 or -CONR3R4 where R3 and R4 are each independently H or C1-C4 alkyl or together with the nitrogen atom …