Method for differential diagnosis of t cell leukemias using monoclonal antibodies
CA 1250241 A · Owner: Sloan-Kettering Institute For Cancer Research A/K/A Memorial Sloan-Kettering Institute Cancer Center · Inventors: Knowles, Robert W.; Dupont, Bo; Morishima, Yasuo
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Its claims, description and drawings are in the Canadian Patents Database.
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Two monoclonal antibodies (3-3 and 3-40) were produced which identify two new leukemia associated antigens. Both antibodies reacted with most cell lines derived from patients with T lymphoblastic leukemia (T-ALL) but were not detected on suspensions of normal hematopoietic cells; including thymocytes, by cytotoxicity absorption of, indirect immunofluorescence assays. Analysis of fresh leukemic cells indicated that mAb 3-3 only reactd with T-ALL cells, while mAb 3-40 reacted with some non-T non-B ALL cells and a few acute myelocytic leukemia (AML) cells as well as T-ALL cells. The 3-40 antigen was also found histopathologically in frozen sections of several normal tissues, including the …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Granted February 21, 1989. A Canadian patent filed before October 1, 1989 lasted 17 years from grant, so its term ended February 21, 2006.
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Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.