Indoline and 2-indolinone derivatives

Abstract From the Canadian patent

This invention provides indoline or 2-indolinone derivatives of the formula, (I), wherein: Ra is hydrogen or methyl;, B=C< is O=C< or H2C<; R1 is hydrogen, C1-C4 alkyl, C2-C4 alkanoyl methyl- or ethyl-sulfonyl, or benzoyl optionally substituted on the phenyl ring with one to three substitutents selected from halo, C1-C4 alkyl, methoxy or ethoxy; R2 is hydrogen, C1-C22 alkyl, hydroxy-substituted C1-C3 alkyl, carbamoyl-substituted C1-C11 alkyl naphthyloxy-methyl or -ethyl, an oxo-substituted C1-C11 alkyl group, or R6R7N-(CH2)n- where each of R6 and R7 is independently hydrogen or C1-C4 alkyl, or when taken together with the nitrogen atom to which they are attached form a pyrrolidino, …