1,5-benzothiazepine derivatives and processes for preparing the same

Abstract From the Canadian patent

This invention provides novel 1,5-benzothiazepine derivatives of the formula:, (I), wherein R1 is lower alkyl or lower alkoxy R2 is hydrogen, atom or lower alkanoyl Ring A is a substituted benzene ring, of the formula: or , Ra is lower alkyl, lower alkoxy, lower alkylthio or benzyloxy each one of Rb and Rc is lower alkyl, lower alkoxy or halogen atom, and either one of Rd and Re is fluorine atom and the other one is hydrogen atom, or a salt thereof. These derivatives (I) and their salts are useful as an intermediate in the synthesis of novel 5-alkyl-1,5-benzothiazepine derivatives which show potent hypotensive activity and potent cerebral or coronary vasodilating activity.