Substituted 1-pyridyloxy-3-indolylalkylamino-2- propanols, preparation, and use thereof

Abstract From the Canadian patent

1-(Pyridinyloxy)-3-(indolylalkylamino)-2-propanols novel, cardiovascular agents having vasodilator activity and a range of adrenergic beta-receptor blocking action are prepared by any, one of three routes that comprise a novel general process. The general process comprises coupling a hydroxyl- or halogensubstituted pyridine with a suitable halogen- or hydroxylsubstituted propanol or incipient propanol intermediate; and the products of these couplings are also novel. In the preferred of the three coupling routes, product 1-(pyridinyloxy)-3- (indolylalkylamino)-2-propanols are formed directly; in the other two coupling routes further processing of the coupling products is required to form the …