Antibodies having dual specificities, their preparation and uses therefor

Abstract From the Canadian patent

Described herein are "polydomas" the product of the, fusion of a hybridoma with a B-lymphocyte or another hybridoma. The polydomas produce a hybrid monoclonal antibody having a dual specificity against two different antigenic determinants. Also described are immunodiagnostic and immunotherapeutic processes which utilize the hybrid monoclonal antibodies or other antibodies having a dual specificity. In those processes one, specificity of the antibody is directed against a target antigen and the other against a moiety which permits a diagnosis to be made or which delivers an agent lethal to the target antigen or associated tissue.