Theophylline immunogens, antibodies, labeled conjugates, and related derivatives

Abstract From the Canadian patent

Theophylline immunogens antibodies prepared there-, from, labeled theophylline conjugates synthetic inter-, mediates, and the use of such antibodies and labeled conjugates in immunoassays for determining theophylline. The immunogens comprise theophylline coupled at its 9-position to an immunogenic carrier material. Likewise the labeled conjugates and synthetic intermediates are 9-position derivatives of theophylline or synthetic precursors thereof. The antibody and labeled reagents are particularly useful in homogeneous nonradioisotopic immunoassays for measuring theophylline in biological fluids such as serum.