Preparation of biaryl compounds
CA 1209159 A · Owner: Ethyl Corporation · Inventors: Ramachandran, Venkataraman
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
Biaryl compounds are prepared by coupling an arylamine with an aromatic compound in the presence of an alkyl nitrite and 0.04-0.6 mol of an acid having a dissociation constant of at least 1.7 x 10-5 at 25°C. and about 0.08-1.3 mols of a cuprous halide catalyst per mol of the arylamine. The invention has particular utility in the coupling with aromatic compounds of arylamines having acid-sensitive ar-substituents e.g. flurbiprofen intermediates, such as 2-(4-amino-3fluorobenzene)propionitrile and alkyl 2-(4-amino-3fluorobenzene)propionates.
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Granted August 5, 1986. A Canadian patent filed before October 1, 1989 lasted 17 years from grant, so its term ended August 5, 2003.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
Timeline From CIPO dates
Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.