Polymer-metal complexes containing quarternary nitrogen atoms, process for preparation thereof and pharmaceutical agents comprising the same

Abstract From the Canadian patent

A novel polymer-metal complex containing quarternary nitrogen atoms, which is obtained by subjecting polyethylenepolyamine or polyethyleneimine to a reaction with a bifunctional compound represented by the formula Y-A-Z, wherein Y and Z are same or different and are -CH2X -CH(OH)CH2Xor -CH-CH2 group, respectively A is a single, bond, -(CH2)m-, -CH2-O-CH2-or -CH2-O(CH2)k-O-CH2-group X is chlorine, bromine or iodine atom, m is an integral of 1 to 3, and k is an integral of 1 to 4 and then, subjecting the resulting cross-linked polymer to a coordination of a polyvalent metal ion a salt thereof, a process for the preparation thereof and a pharmaceutical agent comprising the same. -1-