3,3-dialkyl- and 3,3-alkylene-indoline derivatives, and processes for their production

Abstract From the Canadian patent

3,3-Dialkyl- or 3,3-alkylene-indolines which are unsubstituted at the 1- and 2-positions and which are substituted at the 4- or 6-position by an optionally etherified hydroxy group or substituted at the 5- or 7-position by an etherified hydroxy group, as well as their physiologically-hydrolysable and -acceptable esters. Typical indolines in accordance with the invention are those of formula I, (I), wherein Rl and R2 are each Cl-3alkyl or together are -(CH2)2-5 R3 = OH or Cl-6alkoxy in the 4- or 6-position or Cl-6alkoxy in the 5- or 7-position and R4 = H or Cl-3alkyl. The said indolines are esters as well as their pharmaceutically acceptable acid addition salts possess analgesic activity.