Antibiotic synthesis
CA 1190236 A · Owner: Merck & Co. Inc. · Inventors: Grabowski, Edward J.J.; Reider, Paul J.
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
A new process involving novel intermediates for the synthesis of antibiotics comprises: 1. acylation of a dianion followed by reduction to introduce an arylhydroxymethyl or alkylhydroxymethyl group; alternatively, alkylation followed by oxidation and reduction to introduce the same group; 2. oxidative decarboxylation to introduce a 4-acetoxy group;, 3. silyl enolether chemistry on the acetoxy intermediate using Lewis acids to introduce the side chain, or replacement of the acetoxy group with a triphenylmethylthio group; and, 4. ring closures.
Read the whole patent
Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Granted July 9, 1985. A Canadian patent filed before October 1, 1989 lasted 17 years from grant, so its term ended July 9, 2002.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
Timeline From CIPO dates
Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.