Compositions for treating glaucoma

Abstract From the Canadian patent

Abstract of the Disclosure A method for the treatment of glaucoma or lowering intraocular pressure in a mammal, involving topically administering to the eye of such mammal a selectively metabolized beta-blocking compound of the formula wherein R may be lower alkyl, lower alkynyl aryl, or, aralkyl; A may be a direct bond lower alkylenyl, or, lower alkenyl; x may be an integer from 1 to 3; Ar may be substituted or unsubstituted aromatic; R1 may be lower alkyl, lower hydroxy alkyl, lower alkenyl lower, alkynyl, or aralkyl; and pharmaceutically accepted salts thereof. Because of a relatively long duration of action of such compounds in ocular fluids and a relatively short duration of action in …