Process for the manufacture of novel tri-substituted imidazole derivatives

Abstract From the Canadian patent

This invention relates to novel tri-substituted imidazole derivatives of the general formula I, in which R1 and R2 represent independently either optionally substituted phenyl, or one of R1 and R2, represents an optionally substituted pyrrolyl furyl, thienyl, pyridyl or 1-oxopyridyl group; A represents a straight chain or cyclic lower alkyl group which may be unsaturated; and R3 represents a carboxy group or substituted carboxy group such as an ester or carbamoyl group with the proviso that if (i) A represents methylene or ethylidene and R3 represents, eth? carbamoyl then one of R1 and R2 is other than phenyl and (ii) if A, represents ethylidene and R3 represents carboxy or carbamoyl then …